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Found 24 with Last Name = 'wetzel' and Initial = 's'
TargetEstrogen receptor(Homo sapiens (Human))
Institut FüR Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50323701(2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from human ERalpha ligand binding domain expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50393328(CHEMBL2152123)
Affinity DataIC50:  360nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50:  800nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50040420(4-Methoxy-4-[3-(naphthalen-2-yloxymethyl)-phenyl]-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM4363((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50323700(CHEMBL1213616 | N-(2-(dimethylamino)ethyl)-4-((nap...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50323700(CHEMBL1213616 | N-(2-(dimethylamino)ethyl)-4-((nap...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of LOX5 in human whole blood assessed as inhibition of conversion of aracidonic acid to leukotrineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481906(CHEMBL1075839)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of CDK2/Cyclin BMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50323699(2-(benzyloxy)naphthalene | 2-Benzyloxy-naphthalene...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50323699(2-(benzyloxy)naphthalene | 2-Benzyloxy-naphthalene...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of LOX5 in human whole blood assessed as inhibition of conversion of aracidonic acid to leukotrineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481911(CHEMBL1075809)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481907(CHEMBL1075810)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of His-tagged Cdc25A expressed in the Escherichia coli BL21(DE3) using p-nitrophenyl phosphate as substrate for 80 mins by spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of ERK1/MAPKMore data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481909(CHEMBL1075863)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481908(CHEMBL1075861)
Affinity DataIC50:  9.80E+4nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481910(CHEMBL1075859)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50481912(CHEMBL1075865)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM4363((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Affinity DataIC50:  6.40E+5nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Institut FüR Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50323701(2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...)
Affinity DataEC50:  4.60E+3nMAssay Description:Binding affinity to human ERbeta ligand binding domain expressed in Escherichia coli BL21(DE3) cells assessed as recruitment of fluorescently labeled...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Institut FüR Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50323701(2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...)
Affinity DataEC50:  275nMAssay Description:Binding affinity to human ERalpha ligand binding domain expressed in Escherichia coli BL21(DE3) cells assessed as recruitment of fluorescently labele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed