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Found 970 with Last Name = 'wright' and Initial = 'g'
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225280(CHEMBL3144215)
Affinity DataKi:  1nMAssay Description:Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193475((3R)-3-{[2-({2-[({[(1S)-1-carbamoyl-4-[(diaminomet...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193477(3-((R)-4-(3-(2-(2-(((2R,3S,4R,5R,6R)-5-amino-6-((1...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193487((3R)-3-[(2-{[2-({[(3-{[3-(dimethylamino)propyl]ami...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193484(CID44414951 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193478(CID44415032 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182669((S)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-dif...)
Affinity DataKi:  4nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 2)
Glsynthesis

LigandPNGBDBM21885(2,9-disubstituted 6-oxopurine, 12i | 9-[4-(decahyd...)
Affinity DataKi:  5nM IC50:  13nMAssay Description:Recombinant HSV TKs were assayed in reaction mixture containing substrate [3H-methyl]TdR and test compounds. After reaction was stopped, the radioact...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182665((R)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-dif...)
Affinity DataKi:  7nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193488(CID44415033 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182666(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-8-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182662((S)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluor...)
Affinity DataKi:  11nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193474((R)-4-(3-(2-(2-(((2R,3S,4R,5R,6R)-5-amino-6-((1R,2...)
Affinity DataKi:  11nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182667(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-difluor...)
Affinity DataKi:  11nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182674((R)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluor...)
Affinity DataKi:  12nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193480((R)-4-(3-(2-(2-(((2R,3S,4R,5R,6R)-5-amino-6-((1R,2...)
Affinity DataKi:  12nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182659(3-{4-[1-(1-tert-butyl-3-carboxy-4-oxo-6-fluoro-7-q...)
Affinity DataKi:  13nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182663(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-8-...)
Affinity DataKi:  14nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182673(3-{4-[1-(1-(4-fluorophenyl)-3-carboxy-4-oxo-6-fluo...)
Affinity DataKi:  17nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182676(3-{4-[1-(1-{2,4-difluorophenyl}-3-carboxy-4-oxo-6-...)
Affinity DataKi:  18nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182672(1-ethyl-7-(4-(4-(4-(3-ethyl-4-methylphenylamino)-2...)
Affinity DataKi:  18nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi:  19nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182671(3-{5-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-7-...)
Affinity DataKi:  19nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50176073(3-{4-[Bis-(2-hydroxy-ethyl)-amino]-butyl}-6-(3-eth...)
Affinity DataKi:  21nMAssay Description:Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182670(3-{4-[1-(1-ethyl-3-carboxy-4-oxo-6,8-difluoro-7-qu...)
Affinity DataKi:  21nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129756(3-[4-(4-Benzyl-piperazin-1-yl)-butyl]-6-(3-ethyl-4...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182675(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-7-...)
Affinity DataKi:  24nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182668(3-{4-[1-(1-ethyl-3-carboxy-4-oxo-6-fluoro-7-quinol...)
Affinity DataKi:  24nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129757(3-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl...)
Affinity DataKi:  25nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182656(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-7-...)
Affinity DataKi:  26nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129760((4-{4-[4-(3-Ethyl-4-methyl-phenylamino)-2,6-dioxo-...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50176104(6-(3-Ethyl-4-methyl-phenylamino)-3-(8-hydroxy-octy...)
Affinity DataKi:  26nMAssay Description:Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50176095(6-(3-Ethyl-4-methyl-phenylamino)-3-[4-(2-hydroxy-e...)
Affinity DataKi:  28nMAssay Description:Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129774(6-(3-Ethyl-4-methyl-phenylamino)-3-(4-piperidin-1-...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1)
Glsynthesis

LigandPNGBDBM21885(2,9-disubstituted 6-oxopurine, 12i | 9-[4-(decahyd...)
Affinity DataKi:  30nM ΔG°:  -44.7kJ/mole IC50:  150nMpH: 7.5 T: 2°CAssay Description:Recombinant HSV TKs were assayed in reaction mixture containing substrate [3H-methyl]TdR and test compounds. After reaction was stopped, the radioact...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129778(6-(3-Ethyl-4-methyl-phenylamino)-3-(4-piperazin-1-...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50160350(Acetic acid (R)-5-[2-(3,4-dichloro-benzylamino)-6-...)
Affinity DataKi:  31nMAssay Description:Inhibitory constant against DNA polymerases IIIE from Bacillus subtilis; (a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129762(3-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydr...)
Affinity DataKi:  32nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182657(3-{5-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-7-...)
Affinity DataKi:  33nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50176101(2-Chloro-N-{4-[4-(3-ethyl-4-methyl-phenylamino)-2,...)
Affinity DataKi:  35nMAssay Description:Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50160340(2-(3,4-Dichloro-benzylamino)-7-((R)-5-hydroxy-hexy...)
Affinity DataKi:  35nMAssay Description:Inhibitory constant against DNA polymerases IIIE from Bacillus subtilis; (a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182664(3-{5-[1-(1-ethyl-3-carboxy-4-oxo-6-fluoro-7-quinol...)
Affinity DataKi:  37nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataKi:  38nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129775(6-(3-Chloromethyl-4-methyl-phenylamino)-3-(4-metho...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182658(3-{5-[1-(1-cyclopropyl-3-carboxy-6-fluoro-4-oxo-7-...)
Affinity DataKi:  41nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129769(6-(3-Chloro-4-methyl-phenylamino)-3-(4-methoxy-but...)
Affinity DataKi:  42nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50129781(6-(3-Ethyl-4-methyl-phenylamino)-3-{4-[4-(furan-2-...)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against DNA polymerase IIIC from Bacillus subtilis was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGNAT family acetyltransferase(Enterococcus durans)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193476(CID44415023 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
Affinity DataKi:  43nMAssay Description:Inhibition of Enterococcus faecium AAC(6')IiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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