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Found 483 with Last Name = 'yoakim' and Initial = 'c'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM729((2S,4R)-N-tert-butyl-1-[(2R,3S)-2-hydroxy-3-[(2S)-...)
Affinity DataKi:  0.0310nM ΔG°:  -62.4kJ/mole IC50:  4nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM729((2S,4R)-N-tert-butyl-1-[(2R,3S)-2-hydroxy-3-[(2S)-...)
Affinity DataKi:  0.130nM ΔG°:  -58.7kJ/mole IC50:  10nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053967((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM748((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)
Affinity DataIC50:  1.5nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM747((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)
Affinity DataIC50:  1.60nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM746((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)
Affinity DataIC50:  1.70nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM745((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)
Affinity DataIC50:  1.80nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27583(2-{4-[3-chloro-4-(2-{[1-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27595(2-{4-[3-chloro-4-(2-{[5-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27599(2-{4-[3-chloro-4-(2-{[4-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476896(CHEMBL232576)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50369164(CHEMBL1169533)
Affinity DataIC50:  2nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50369164(CHEMBL1169533)
Affinity DataIC50:  2nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10227(5-chloro-2-ethyl-7-methyl-13-[(pyridin-4-ylsulfany...)
Affinity DataIC50:  2.20nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27584(2-{4-[3-chloro-4-(2-{[1-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27591(2-{4-[3-chloro-4-(2-{[1-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataIC50:  2.60nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476895(CHEMBL232379)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053968((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50:  3nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050831((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-2-[3-(1-ethyl-p...)
Affinity DataIC50:  3nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM2058(2,8-disubstituted dipyridodiazepinone 41 | 2-Chlor...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476903(CHEMBL230188)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27607(4-[3-chloro-4-(2-{[1-(2-chloro-4-cyclopropylphenyl...)
Affinity DataIC50:  3.70nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10235(13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]methyl}-2-...)
Affinity DataIC50:  4.20nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476897(CHEMBL232178)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053981((S)-2-((S)-3-Carboxy-2-{(2R,5S)-2-(3,3-dimethyl-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476898(CHEMBL232377)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476904(CHEMBL232575)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476885(CHEMBL231030)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053973((S)-3-((S)-2-{(S)-2-[3-(1-Ethyl-propyl)-ureido]-3,...)
Affinity DataIC50:  6nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10232(5-chloro-13-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10234(13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]methyl}-2-...)
Affinity DataIC50:  6.90nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50053984((S)-2-{(S)-3-Carboxy-2-[(2S,5S)-5-[3-(1-ethyl-prop...)
Affinity DataIC50:  7nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
Bio-M£Ga/Boehringer Ingelheim Research

Curated by ChEMBL
LigandPNGBDBM50050828((S)-2-[(S)-3-Carboxy-2-((S)-2-{(S)-3-methyl-2-[3-(...)
Affinity DataIC50:  7nMAssay Description:Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM741((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)
Affinity DataIC50:  7nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10230(5-chloro-13-{[(2,6-dimethylpyridin-4-yl)sulfanyl]m...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27590(2-{4-[4-(2-{[1-(4-tert-butyl-2-chlorophenyl)-1H-1,...)
Affinity DataIC50:  7.70nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476894(CHEMBL230187)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27592(2-{4-[3-chloro-4-(2-{[1-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  7.90nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476899(CHEMBL232963)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim (Canada)

LigandPNGBDBM10233(13-[(1,3-benzoxazol-2-ylsulfanyl)methyl]-5-chloro-...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  8.40nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27589(2-{[1-(2-chloro-4-methylphenyl)-1H-1,2,3,4-tetrazo...)
Affinity DataIC50:  8.80nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476896(CHEMBL232576)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27597(2-{4-[3-chloro-4-(2-{[1-(2-chloro-4-methylphenyl)-...)
Affinity DataIC50:  9.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM27606(2-{[1-(naphthalen-1-yl)-1H-1,2,3,4-tetrazol-5-yl]s...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Boehringer Ingelheim (Canada)

LigandPNGBDBM27606(2-{[1-(naphthalen-1-yl)-1H-1,2,3,4-tetrazol-5-yl]s...)
Affinity DataIC50:  9.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476909(CHEMBL232378)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50476893(CHEMBL393190)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV1 reverse transcriptase by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50171982(4-[2-(7-Chloro-5-ethyl-10-methyl-11-oxo-10,11-dihy...)
Affinity DataIC50:  10nMpH: 7.8Assay Description:Inhibitory activity of compound dissolved in DMSO was determined against HIV-1 wild type reverse transcriptase (1-2 nM) by using [3H]-dGTP (71 nM) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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