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Found 1319 with Last Name = 'zheng' and Initial = 'h'
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  0.190nMAssay Description:ATP competitive inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nM ΔG°:  -54.5kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  0.5nM ΔG°:  -54.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  0.5nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)
Affinity DataKi:  0.700nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  1nM ΔG°:  -52.2kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50510071(CHEMBL4541082)
Affinity DataKi:  1.90nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50510072(CHEMBL4435339)
Affinity DataKi:  2.5nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50416603(CHEMBL1222883)
Affinity DataKi:  3.10nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50125136(2-[2,3']Bipyridinyl-6'-yl-1-(2,3-dihydro-benzofura...)
Affinity DataKi:  4nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]ketanserin from 5-HT2A receptor in human frontal cortex after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50125136(2-[2,3']Bipyridinyl-6'-yl-1-(2,3-dihydro-benzofura...)
Affinity DataKi:  4nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50036629(Avanafil | CHEBI:66876 | Stendra | TA-1790)
Affinity DataKi:  5nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308541(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308537(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  6.92nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467496(CHEMBL4277253)
Affinity DataKi:  8nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50118253(1-Benzo[1,3]dioxol-5-yl-2-[5-(3,4-dimethoxy-phenyl...)
Affinity DataKi:  8nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50118253(1-Benzo[1,3]dioxol-5-yl-2-[5-(3,4-dimethoxy-phenyl...)
Affinity DataKi:  8.90nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308538(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  9.37nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308539(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]raclopride from D2 receptor in human corpus striatum after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor in human frontal cortex after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  19nMAssay Description:ATP competitive inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308546(2-Chloro-7-methoxy-8-pentyloxy-1-quinoline-3-carbo...)
Affinity DataKi:  23.8nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308540(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  27.9nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  42nMAssay Description:ATP competitive inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50510070(CHEMBL2218191)
Affinity DataKi:  54nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150119(CHEMBL3769414)
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant full lenght human PDE4A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150241(CHEMBL3770585)
Affinity DataKi:  65nMAssay Description:Inhibition of recombinant full lenght human PDE4A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50016469(CHEMBL514709)
Affinity DataKi:  93nMAssay Description:Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  98nMAssay Description:ATP competitive inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50016480(CHEMBL3265104)
Affinity DataKi:  100nMAssay Description:Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataKi:  110nMAssay Description:Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50016470(CHEMBL3265094)
Affinity DataKi:  140nMAssay Description:Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50016478(CHEMBL3265103)
Affinity DataKi:  140nMAssay Description:Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50016476(CHEMBL3265101)
Affinity DataKi:  140nMAssay Description:Binding affinity to MDM2 (1 to 118) (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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