Compile Data Set for Download or QSAR
maximum 50k data
Found 260 with Last Name = 'de fex' and Initial = 'h'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13277(BMS-354825 2-Heteroarylamino-thiazole Analog 12v |...)
Affinity DataIC50:  0.200nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13271(BMS-354825 2-Heteroarylamino-thiazole Analog 12p |...)
Affinity DataIC50: <0.200nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13262(BMS-354825 2-Heteroarylamino-thiazole Analog 12g |...)
Affinity DataIC50:  0.300nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.400nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13274(BMS-354825 2-Heteroarylamino-thiazole Analog 12s |...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >0.5nMAssay Description:Inhibition of Lyn kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13272(BMS-354825 2-Heteroarylamino-thiazole Analog 12q |...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13266(BMS-354825 2-Heteroarylamino-thiazole Analog 12k |...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13273(2-(6-(3-(1H-Imidazol-1-yl)propylamino)pyridin-2-yl...)
Affinity DataIC50: <0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13357(CHEMBL312933 | N-(2-chloro-6-methylphenyl)-2-({6-[...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13265(BMS-354825 2-Heteroarylamino-thiazole Analog 12j |...)
Affinity DataIC50:  0.600nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13278(BMS-354825 2-Heteroarylamino-thiazole Analog 12w |...)
Affinity DataIC50:  0.700nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13276(BMS-354825 2-Heteroarylamino-thiazole Analog 12u |...)
Affinity DataIC50:  0.700nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)
Affinity DataIC50: <1nMAssay Description:Inhibitory activity against Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13268(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)
Affinity DataIC50:  1nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)
Affinity DataIC50: <1nMAssay Description:Inhibitory activity against Fgr kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)
Affinity DataIC50:  1nMAssay Description:inhibitory activity against Fyn protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120101((2-Chloro-6-methyl-phenyl)-[8-(4-methyl-piperazin-...)
Affinity DataIC50:  1nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13256(BMS-354825 2-Heteroarylamino-thiazole Analog 12a |...)
Affinity DataIC50:  1.20nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13259(BMS-354825 2-Heteroarylamino-thiazole Analog 12d |...)
Affinity DataIC50:  1.20nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13275(BMS-354825 2-Heteroarylamino-thiazole Analog 12t |...)
Affinity DataIC50:  1.30nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120116(CHEMBL108362 | N*4*-(2-Chloro-6-methyl-phenyl)-N*7...)
Affinity DataIC50:  1.70nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13268(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)
Affinity DataIC50:  2nMAssay Description:inhibitory activity against Hck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120094((2-Chloro-6-methyl-phenyl)-(7,8-dimethoxy-imidazo[...)
Affinity DataIC50:  2nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120087((2-Chloro-6-methyl-phenyl)-[8-(4-ethyl-piperazin-1...)
Affinity DataIC50:  2nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50112911((2-Chloro-6-methyl-phenyl)-(6,7-dimethoxy-imidazo[...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120090(CHEMBL108686 | N*4*-(2-Chloro-6-methyl-phenyl)-N*8...)
Affinity DataIC50:  2nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120125((2-Chloro-6-methyl-phenyl)-[8-methoxy-7-(2-morphol...)
Affinity DataIC50:  2.40nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120097((7,8-Dimethoxy-imidazo[1,5-a]quinoxalin-4-yl)-(2,6...)
Affinity DataIC50:  2.40nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50112947((6,7-Dimethoxy-imidazo[1,5-a]quinoxalin-4-yl)-(2,6...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >2.80nMAssay Description:Inhibition of Fgr protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120127(CHEMBL106213 | N*4*-(2-Chloro-6-methyl-phenyl)-N*7...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120093((2-Chloro-6-methyl-phenyl)-(8-piperazin-1-yl-imida...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120130(CHEMBL110732 | N-(4-(2-chloro-6-methylphenylamino)...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120089((2-Chloro-6-methyl-phenyl)-[8-(3,5-dimethyl-pipera...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120109((2-Chloro-6-methyl-phenyl)-(8-methoxy-imidazo[1,5-...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13270(2-[(2,6-dimethylpyrimidin-4-yl)amino]-N-(2,4,6-tri...)
Affinity DataIC50:  3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120128(CHEMBL325986 | N*4*-(2-Chloro-6-methyl-phenyl)-N*8...)
Affinity DataIC50:  3nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120104(4-(2-Chloro-6-methyl-phenylamino)-imidazo[1,5-a]qu...)
Affinity DataIC50:  4nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120111((2-Chloro-6-methyl-phenyl)-(8-morpholin-4-yl-imida...)
Affinity DataIC50:  4nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13267(BMS-354825 2-Heteroarylamino-thiazole Analog 12l |...)
Affinity DataIC50:  4nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13261(BMS-354825 2-Heteroarylamino-thiazole Analog 12f |...)
Affinity DataIC50:  4nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120113((2-chloro-6-methyl-phenyl)-(7,9-dioxa-2,5,10b-tria...)
Affinity DataIC50:  4nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50112938((E)-4-(2-chloro-6-methylphenylamino)-6,7-dimethoxy...)
Affinity DataIC50:  4.30nMAssay Description:Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >4.70nMAssay Description:Inhibition of Yes kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13264(2-(pyrazin-2-ylamino)-N-(2,4,6-trimethylphenyl)-1,...)
Affinity DataIC50:  4.90nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50120115(CHEMBL321862 | N*4*-(2-Chloro-6-fluoro-phenyl)-N*7...)
Affinity DataIC50:  5nMAssay Description:50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >5nMAssay Description:Inhibition of Fyn protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13260(2-(pyridin-2-ylamino)-N-(2,4,6-trimethylphenyl)-1,...)
Affinity DataIC50:  5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 260 total ) | Next | Last >>
Jump to: