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Found 125 with Last Name = 'van den heuvel' and Initial = 'm'
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414981(CHEMBL567417)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414959(CHEMBL409224)
Affinity DataIC50:  2.51nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414982(CHEMBL579072)
Affinity DataIC50:  2.63nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414974(CHEMBL568523)
Affinity DataIC50:  2.63nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414980(CHEMBL568294)
Affinity DataIC50:  2.82nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198484(5-(5-((2-(benzofuran-4-yl)ethylamino)methyl)pyridi...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414983(CHEMBL574655)
Affinity DataIC50:  4.90nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414986(CHEMBL568522)
Affinity DataIC50:  5.62nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198461(5-(5-((2-chlorophenethylamino)methyl)pyridin-2-yl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414958(CHEMBL259243)
Affinity DataIC50:  6.46nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414975(CHEMBL584087)
Affinity DataIC50:  6.61nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198462(5-(5-((biphenyl-4-ylmethylamino)methyl)pyridin-2-y...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198480(5-(5-((2-chlorobenzylamino)methyl)pyridin-2-yl)-N-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198469(CHEMBL441699 | N-hydroxy-5-(5-((2-methylphenethyla...)
Affinity DataIC50:  8nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198473(5-(5-((2-(1H-indol-3-yl)ethylamino)methyl)pyridin-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198475(5-(5-((benzo[d][1,3]dioxol-5-ylmethylamino)methyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414978(CHEMBL566543)
Affinity DataIC50:  8.13nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198478(5-(5-(2-(benzylamino)ethyl)pyridin-2-yl)-N-hydroxy...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198470(CHEMBL436964 | N-hydroxy-5-(5-((3-methylphenethyla...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198454(5-(5-((4-chlorobenzylamino)methyl)pyridin-2-yl)-N-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198463(5-(5-((4-fluorophenethylamino)methyl)pyridin-2-yl)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198472(5-(5-(2-(benzo[d][1,3]dioxol-5-ylmethylamino)ethyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198453(5-(5-(((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198465(CHEMBL387247 | N-hydroxy-5-(5-((2-phenoxyethylamin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414964(CHEMBL271128)
Affinity DataIC50:  11.5nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198466(5-(5-((2-fluorophenethylamino)methyl)pyridin-2-yl)...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198455(CHEMBL217531 | N-hydroxy-5-(5-((phenethylamino)met...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198464(5-(5-(2-(4-fluorobenzylamino)ethyl)pyridin-2-yl)-N...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198468(CHEMBL216896 | N-hydroxy-5-(5-((4-methylphenethyla...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414966(CHEMBL573216)
Affinity DataIC50:  14.8nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198483(5-(5-((benzylamino)methyl)pyridin-2-yl)-N-hydroxyt...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198474(CHEMBL263570 | N-hydroxy-5-(5-((phenylamino)methyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198458(CHEMBL385934 | N-hydroxy-5-(5-((2-methoxyphenethyl...)
Affinity DataIC50:  17nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414967(CHEMBL271801)
Affinity DataIC50:  17.4nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198456(CHEMBL217529 | N-hydroxy-5-(5-((3-phenylpropylamin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414957(CHEMBL429436)
Affinity DataIC50:  19.1nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414976(CHEMBL566324)
Affinity DataIC50:  22.4nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414977(CHEMBL567627)
Affinity DataIC50:  22.4nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414968(CHEMBL410885)
Affinity DataIC50:  27.5nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198218(5-(1-(2-(benzo[d][1,3]dioxol-5-ylmethylamino)ethyl...)
Affinity DataIC50:  29nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198482(5-(5-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414964(CHEMBL271128)
Affinity DataIC50:  30.2nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414979(CHEMBL583621)
Affinity DataIC50:  30.9nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198471(CHEMBL279353 | N-hydroxy-5-(5-(2-(phenethylamino)e...)
Affinity DataIC50:  31nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414969(CHEMBL272022)
Affinity DataIC50:  32.4nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414959(CHEMBL409224)
Affinity DataIC50:  34.7nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50198459(5-(5-((benzyl(methyl)amino)methyl)pyridin-2-yl)-N-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of HDAC activity measured by HDAC Fluorescent Activity Assay (mean of two experiments)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414964(CHEMBL271128)
Affinity DataIC50:  45.7nMAssay Description:Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414970(CHEMBL583843)
Affinity DataIC50:  55.0nMAssay Description:Antagonist activity at human CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50414966(CHEMBL573216)
Affinity DataIC50:  70.8nMAssay Description:Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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