Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 16497,16499,16500,16501,16506,16508,16510,16497,16499,16500,16501,16506,16508,16510   

TargetCathepsin B(Human)
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataIC50: 1.53nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2009
Entry Details
PCBioAssay
TargetProcathepsin L(Human)
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataIC50: 1.63nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetCathepsin B(Human)
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM16508((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataKi:  3.36nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataIC50: 3.61nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details
PCBioAssay
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16499(CA inhibitor 2 | EtO-tES-Ile-Ala-OH | CA075 | (2S)...)
Affinity DataIC50: 23nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16500(CA inhibitor 3 | EtO-tES-Ile-Ile-OH | (2S)-2-[(2S,...)
Affinity DataIC50: 24nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataIC50: 40nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16508((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)
Affinity DataIC50: 120nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16501(EtO-tES-Thr-Ile-OH | (2S)-2-[(2S,3R)-2-{[(2S,3S)-3...)
Affinity DataIC50: 410nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetPapain(Papaya)
University of Wisconsin

Curated by ChEMBL
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataKi:  2.40E+3nMpH: 6.8Assay Description:Kinetic constant Apparent binding constant (Ki`) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16506(CA inhibitor 9 | (2S)-1-(2-{[(2S,3S)-3-(ethoxycarb...)
Affinity DataIC50: 1.53E+4nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16497((2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]...)
Affinity DataIC50: 2.40E+4nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed