Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 24634,24636,24638,24639,24640,50113282,24634,24636,24638,24639,24640,50113282   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system using fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50: 417nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system using 5-FAM-peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
LigandPNGBDBM24640(N-(4-fluorophenyl)-4-(2-hydroxyacetamido)-1H-pyraz...)
Affinity DataIC50: 730nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
LigandPNGBDBM24639(4-acetamido-N-(4-fluorophenyl)-1H-pyrazole-3-carbo...)
Affinity DataIC50: 850nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
LigandPNGBDBM50113282(CHEMBL456163)
Affinity DataIC50: 850nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50: 3.00E+3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM24638(4-amino-N-(4-fluorophenyl)-1H-pyrazole-3-carboxami...)
Affinity DataIC50: 8.50E+4nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
LigandPNGBDBM24636(N-phenyl-1H-pyrazole-3-carboxamide | pyrazole amid...)
Affinity DataIC50: 9.70E+4nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed