Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 28394,28395,28396,28397,28398,50383272,28394,28395,28396,28397,28398,50383272   

TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50383272(CHEMBL2032375)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28397((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Affinity DataIC50: 12nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28397((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28395((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28395((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Affinity DataIC50: 33nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 40nMAssay Description:Competitive inhibition of PIM2 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28398((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyridin-2...)
Affinity DataIC50: 46nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28398((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyridin-2...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 57nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 57nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM28396((2E)-3-(3-{6-[(3-methoxypropyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 370nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28396((2E)-3-(3-{6-[(3-methoxypropyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 480nMpH: 7.5 T: 2°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed