Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50065794,50145359,50145364,50145366,50145371,50383268,50065794,50145359,50145364,50145366,50145371,50383268   

TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145364(2-(3,5-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145359(2-(3,4-dihydroxybenzylcarbamoyl)-8-hydroxyquinolin...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of mouse DYRK1A expressed in Escherichia coli after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro inhibition of recombinant integrase activity in a standard 3'-processing assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50145359(2-(3,4-dihydroxybenzylcarbamoyl)-8-hydroxyquinolin...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro inhibition of recombinant integrase activity in a standard 3'-processing assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145366(8-Hydroxy-2-(N'-phenyl-hydrazinocarbonyl)-quinolin...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of DYRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3alpha/betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50383268(CHEMBL2032371)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM50145371(2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50145364(2-(3,5-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of recombinant integrase activity in a standard 3'-processing assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against HIV-1 Integrase in strand transfer (integration)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.00E+5nMAssay Description:HIV integrase inhibitory potency was evaluated as IC50 on 3' processing of target DNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Silesia

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against HIV-1 Integrase in 3'-end- processingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Silesia

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV1 integrase 3' processing activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50145366(8-Hydroxy-2-(N'-phenyl-hydrazinocarbonyl)-quinolin...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of recombinant integrase activity in a standard 3'-processing assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Cnrs Umr 8076

Curated by ChEMBL
LigandPNGBDBM50065794(8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...)
Affinity DataIC50: 1.14E+5nMAssay Description:In vitro anti-HIV integrase activity against integration (strand transfer) of target plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
New York University

US Patent
LigandPNGBDBM50145364(2-(3,5-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinol...)
Affinity DataIC50: 2.32E+5nMAssay Description:Commercially available 2-Hydroxyisoquinoline-1,3(2H,4H)-dione (CAS No: 6890-08-0), a well-known scaffold backbone used to develop human immunodeficie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
New York University

US Patent
LigandPNGBDBM50145359(2-(3,4-dihydroxybenzylcarbamoyl)-8-hydroxyquinolin...)
Affinity DataIC50: 5.51E+5nMAssay Description:Commercially available 2-Hydroxyisoquinoline-1,3(2H,4H)-dione (CAS No: 6890-08-0), a well-known scaffold backbone used to develop human immunodeficie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent