Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50095994,50095995,50095996,50096003,50096007,50096008,50265450,50095994,50095995,50095996,50096003,50096007,50096008,50265450   

Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Liaocheng University

Curated by ChEMBL
LigandPNGBDBM50095995(7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethy...)
Affinity DataKi:  94nMAssay Description:Binding affinity to PFKFB3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Liaocheng University

Curated by ChEMBL
LigandPNGBDBM50095995(7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethy...)
Affinity DataIC50: 183nMAssay Description:Inhibition of PFKFB3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  240nMAssay Description:Inhibition of human CA IX by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  240nM ΔG°:  -8.39kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  370nM ΔG°:  -8.15kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | CHEMBL153505 | ...)
Affinity DataKi:  470nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | CHEMBL153505 | ...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | CHEMBL153505 | ...)
Affinity DataKi:  1.17E+3nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096007(2-Oxo-2H-chromene-3-carboxylic acid 2-oxo-2-phenyl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50265450(2-oxo-2-phenylethyl 7-hydroxy-2-oxo-2H-chromene-3-...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | CHEMBL153505 | ...)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  1.87E+3nM ΔG°:  -7.26kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  2.27E+3nM ΔG°:  -7.15kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  2.98E+3nM ΔG°:  -7.00kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50096008(CHEMBL153064 | 3-acetyl-7-hydroxy-2H-chromen-2-one...)
Affinity DataEC50:  4.14E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096008(CHEMBL153064 | 3-acetyl-7-hydroxy-2H-chromen-2-one...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096008(CHEMBL153064 | 3-acetyl-7-hydroxy-2H-chromen-2-one...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  5.34E+3nM ΔG°:  -6.68kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095996(3-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-3-oxo-propioni...)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 14(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  6.25E+3nM ΔG°:  -6.59kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  7.11E+3nM ΔG°:  -6.52kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095995(7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethy...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095995(7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethy...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095995(7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethy...)
Affinity DataKi:  1.24E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50095995(7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethy...)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096008(CHEMBL153064 | 3-acetyl-7-hydroxy-2H-chromen-2-one...)
Affinity DataIC50: 4.52E+4nMAssay Description:Inhibition of human MIF tautomerase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50096008(CHEMBL153064 | 3-acetyl-7-hydroxy-2H-chromen-2-one...)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi:  1.04E+5nM ΔG°:  -5.05kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi: >2.00E+5nM ΔG°: >-4.69kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human CA II by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCarbonic anhydrase 4(Human)
Ecole Nationale Superieure De Chimie De Montpellier

LigandPNGBDBM50095994(7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile | CHEMB...)
Affinity DataKi: >2.00E+5nM ΔG°: >-4.69kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2017
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | CHEMBL153505 | ...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details
PCBioAssay
TargetTyrosinase(Human)
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | CHEMBL153505 | ...)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed