Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50128671,50343079,50343080,50343081,50343082,50128671,50343079,50343080,50343081,50343082   

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128671(4-(4-butoxyphenylsulfonyl)-N-hydroxy-1-(2-phenoxye...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128671(4-(4-butoxyphenylsulfonyl)-N-hydroxy-1-(2-phenoxye...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  28nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  44nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  80nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  110nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  160nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  170nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  230nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  240nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50128671(4-(4-butoxyphenylsulfonyl)-N-hydroxy-1-(2-phenoxye...)
Affinity DataIC50: 270nMAssay Description:In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  410nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128671(4-(4-butoxyphenylsulfonyl)-N-hydroxy-1-(2-phenoxye...)
Affinity DataIC50: 2.90E+3nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  8.60E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed