Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50303420,50303421,50303422,50303436,50303437,50303420,50303421,50303422,50303436,50303437   

TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303422(cid_44142124 | CHEMBL578162 | 6-(3-chlorophenylami...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303421(6-(3-Chlorophenylamino)-9-ethyl-9H-purine-2-carbon...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303421(6-(3-Chlorophenylamino)-9-ethyl-9H-purine-2-carbon...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303437(9-cyclopentyl-6-(3,5-difluorophenylamino)-9H-purin...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 34.7nMAssay Description:Inhibition of human Cathepsin CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303422(cid_44142124 | CHEMBL578162 | 6-(3-chlorophenylami...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetPapain(Papaya)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 44.7nMAssay Description:Inhibition of papaya papainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 933nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of human Cathepsin CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetKallikrein-4(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibition of human Kallikrein 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetKallikrein-4(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human Kallikrein 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCaspase-1(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human Caspase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCaspase-4(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 3.31E+4nMAssay Description:Inhibition of human Caspase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCorticotropin-releasing factor-binding protein(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50303422(cid_44142124 | CHEMBL578162 | 6-(3-chlorophenylami...)
Affinity DataEC50: >5.30E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetMatrix metalloproteinase-14(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 7.24E+4nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibition of human TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProteinase K(Engyodontium album)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibition of human Proteinase KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 8.51E+4nMAssay Description:Inhibition of human ElastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetChymase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition of human ChymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin G(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.48E+5nMAssay Description:Inhibition of human Cathepsin GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 4.27E+5nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed