Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 81731,50343360,50343361,50343362,50343363,81731,50343360,50343361,50343362,50343363   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM81731(HSP90 Inhibitor, 5)
Affinity DataKd:  12nMAssay Description:Binding affinity to human N-terminal ATPase domain of Hsp90 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

LigandPNGBDBM81731(HSP90 Inhibitor, 5)
Affinity DataKi:  60nM ΔG°:  -9.85kcal/molepH: 7.5 T: 2°CAssay Description:HSP90 inhibitors identified using Fluorescence resonance energy transfer assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50343360(4-Chloro-6-(2-methoxyphenyl)-pyrimidin-2-ylamine |...)
Affinity DataKd:  350nMAssay Description:Binding affinity to human N-terminal ATPase domain of Hsp90 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

LigandPNGBDBM50343362(4-(2-chloro-6-methoxyphenyl)-6-methylpyrimidin-2-a...)
Affinity DataKi:  700nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

LigandPNGBDBM50343360(4-Chloro-6-(2-methoxyphenyl)-pyrimidin-2-ylamine |...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

LigandPNGBDBM50343363(2-(2-amino-6-methylpyrimidin-4-yl)-3-chlorophenol ...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Abbott Laboratories

LigandPNGBDBM50343361(4-(2-methoxyphenyl)-6-methylpyrimidin-2-amine | CH...)
Affinity DataKi:  8.30E+3nMAssay Description:Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50343361(4-(2-methoxyphenyl)-6-methylpyrimidin-2-amine | CH...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HSP90 in human H1299 cells assessed as degradation of Akt protein after 24 hrs by luminex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed