Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 94 hits for monomerid = 9503,9504,84749,50121980,50132151,50132152,50176996,9503,9504,84749,50121980,50132151,50132152,50176996   

LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation expressed in CHO cells in presence of 8 uM ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells measured after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 by cell-based ELISA in presence of 8 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGFR2 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2006
Entry Details Article
PubMed
LigandPNGBDBM50132151(N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benz...)
Affinity DataKi:  15nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 15nMAssay Description:Inhibition of VEGFR1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM84749(N-(3-methylphenyl)-2-(pyridin-4-ylmethylamino)benz...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:In a representative synthetic procedure (compound 3), a mixture of 1 (330 mg, 2 mM) and 3-F3C-C6H4-NHNH2 (370 mg, 2.1 mM) in anisole (20 mL) was stir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant GST-fused VEGFR3 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 18nMAssay Description:Inhibition of VEGFR-3 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50132151(N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benz...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132151(N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benz...)
Affinity DataIC50: 20nMAssay Description:Inhibition of KDR by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant GST-fused VEGFR2 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of KDR by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of VEGFR2 by HTRF assay in presence of 8 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant KDR at 1 uM by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 32nMAssay Description:Inhibition of VEGFR2 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 32nMAssay Description:Inhibition of VEGFR1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 32nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 32nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 32nMT: 2°CAssay Description:In a representative synthetic procedure (compound 3), a mixture of 1 (330 mg, 2 mM) and 3-F3C-C6H4-NHNH2 (370 mg, 2.1 mM) in anisole (20 mL) was stir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 32nMAssay Description:Inhibition of VEGFR2 by HTRF assay in presence of 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 39nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGFR2 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM9504(CHEMBL202011 | 2-[(pyridin-4-ylmethyl)amino]-N-(qu...)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 52nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 55nMAssay Description:Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50176996(CHEMBL3813969)
Affinity DataKi:  64nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR2 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 90nMAssay Description:Inhibition of VEGFR2 expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 99nMAssay Description:In vitro inhibition of Colony stimulating factor 1 receptor (CSF-1R) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50121980(N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmeth...)
Affinity DataIC50: 105nMAssay Description:In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant GST-fused VEGFR1 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 130nMAssay Description:Inhibition of VEGFR1 assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 130nMAssay Description:Inhibition of VEGFR-1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 130nMAssay Description:Inhibition of VEGFR1 by HTRF assay in presence of 8 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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