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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 0.810nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 0.900nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.10nMAssay Description:Displacement of [125I]RTI55 from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.10nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.10nMAssay Description:Displacement of [3H]Citalopram from human SERT by liquid scintillation countingMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.10nM ΔG°: -50.6kJ/mole EC50: 7.30nMpH: 7.4 T: 2°CAssay Description:Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...More data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM81875(Fluoxetine-R-(-))

Ki: 1.40nMMore data for this Ligand-Target Pair

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MCE
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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.96nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.96nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2nMAssay Description:Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.20nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.20nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.20nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.70nMAssay Description:Displacement of [3H]paroxetine from rat cortical 5HTT reuptake siteMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.70nMAssay Description:Displacement of [3H]paroxetine from 5HT transporter in rat cortical membraneMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.72nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.80nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.90nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.90nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.90nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.17nMAssay Description:Evaluated for affinity at 5-HT uptake site using [3H]paroxetine as radioligand in radioligand binding assayMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.5nMAssay Description:Compound was evaluated for its binding affinity towards human serotonin transporterMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.90nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in Sprague-Dawley rat cortical membranesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.90nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.60nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat whole brain membranes after 1 hr by liquid scintillation spectrophotometric analysisMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.70nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Alpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 6.30nMAssay Description:Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cellMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 6.80nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30nMAssay Description:Inhibition of high affinity re-uptake of [3H]5-HT (serotonin) into nerve ending synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30nMAssay Description:Inhibition of [3H]5-HT uptake by Serotonin transporter of rat midbrain or parietal synaptosomesMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30nMAssay Description:Inhibition of [3H]-5-HT uptake into rat synaptosomes by Serotonin transporterMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 8.70nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat SERTMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 9.58nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 10nMAssay Description:In vitro binding affinity was determined against serotonin reuptake site of rat in presence of [3H]paroxetine radioligandMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 10.3nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 10.8nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 10.9nMMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 11nMAssay Description:Tested in vitro for serotonin(5-HT) neuronal uptake inhibitionMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 12.2nMAssay Description:Inhibition of SERT in rat cerebral cortex assessed as [3H]serotonin accumulationMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM81875(Fluoxetine-R-(-))

Ki: 13nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 14nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 20nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 22nMAssay Description:Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 22nMAssay Description:Displacement of [3H]citalopram from rat cortical serotonin transporter (SERT)More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 24.0nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: 30.8nMAssay Description:Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 31nMAssay Description:Displacement of [3H]citalopram from human SERT in HEK293 cells by Topcount scintillation analysisMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 41nMAssay Description:Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 42.6nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 48nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 48nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 50nMMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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5-hydroxytryptamine receptor 2C(PORCINE)
Emory University

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 64nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 72nMAssay Description:Binding affinity to human 5HT2C receptor by radioligand displacement assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(PORCINE)
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 72nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 85nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 85.3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 109nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor in Sprague-Dawley rat choroid plexus membranes after 30 mins by liquid scintillation spectrophot...More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 112nMMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 119nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 141nMMore data for this Ligand-Target Pair

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Transporter(Rattus norvegicus)
Hong Kong University Of Science And Technology

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 143nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 148nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 148nMMore data for this Ligand-Target Pair

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Beta-arrestin-2(Beef)
Eli Lilly

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 155nMMore data for this Ligand-Target Pair

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Transporter(Rattus norvegicus (rat))
Wayne State University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 158nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 160nMMore data for this Ligand-Target Pair

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Transporter(Rattus norvegicus)
Hong Kong University Of Science And Technology

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 167nMAssay Description:Ability to inhibit high affinity reuptake of [3H]-NE (Norepinephrine transporter) into nerve ending synaptosomes prepared from brain regionsMore data for this Ligand-Target Pair

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Transporter(Rattus norvegicus)
Hong Kong University Of Science And Technology

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 176nMAssay Description:Inhibition of [3H]NE uptake by Norepinephrine transporter of rat occipital cortex synaptosomesMore data for this Ligand-Target Pair

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Transporter(Rattus norvegicus)
Hong Kong University Of Science And Technology

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 176nMAssay Description:Inhibition of norepinephrine transporter by inhibition of [3H]-NE uptake into rat nerve endings (synaptosomes)More data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 240nMMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 240nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 245nMMore data for this Ligand-Target Pair

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Beta-arrestin-2(Beef)
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 269nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 270nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 280nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 299nMMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 370nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 398nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 410nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 440nMAssay Description:Binding inhibition towards human norepinephrine transporterMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 473nMMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Transporter(Rattus norvegicus (rat))
Wayne State University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 473nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter in Sprague-Dawley rat frontal cortex after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(RAT)
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 512nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 574nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mayo Clinic

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BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 590nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 599nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 617nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 686nMMore data for this Ligand-Target Pair

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MCE
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Norepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 688nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 702nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 708nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 710nMMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 740nMMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 777nMMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 784nMAssay Description:Displacement of [3H]WIN 35428 from dopamine transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 784nMMore data for this Ligand-Target Pair

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Transporter(Rattus norvegicus)
Hong Kong University Of Science And Technology

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 794nMAssay Description:In vitro binding affinity was determined against NA (noradrenaline) reuptake site of rat in presence of [3H]nisoxetine radioligandMore data for this Ligand-Target Pair

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Histamine H1 receptor(Cavia porcellus (domestic guinea pig))
Emory University

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 812nMMore data for this Ligand-Target Pair

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Histamine H1 receptor(Cavia porcellus (domestic guinea pig))
Emory University

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BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 933nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 998nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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Serotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.02E+3nMMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.03E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.09E+3nMAssay Description:Inhibition of DAT in rat striatum assessed as [3H]dopamine accumulationMore data for this Ligand-Target Pair

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Histamine H1 receptor(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.10E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.35E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: 1.53E+3nMMore data for this Ligand-Target Pair

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MCE
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Histamine H1 receptor(Cavia porcellus (domestic guinea pig))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.55E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.56E+3nM EC50: 1.02E+3nMAssay Description:Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...More data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.56E+3nMAssay Description:Displacement of [125I]RTI55 from human recombinant NET expressed in HEK293 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: 1.66E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 6(RAT)
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.77E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.82E+3nMMore data for this Ligand-Target Pair

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CHEMBL DrugBank MCE
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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.90E+3nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >2.00E+3nMAssay Description:Tested in vitro for serotonin(5-HT) neuronal uptake inhibitionMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Transporter(Rattus norvegicus (rat))
Wayne State University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.00E+3nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.00E+3nMAssay Description:Inhibition constant against norepinephrine transporterMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.08E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.19E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >2.50E+3nMAssay Description:Inhibition of [3H]DA uptake by dopamine transporter of rat striata synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >2.50E+3nMAssay Description:Inhibition of [3H]-DA uptake at Dopamine transporter into rat nerve endings (synaptosomes)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.70E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.70E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-2C adrenergic receptor(RAT)
TBA

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.80E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.90E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.05E+3nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.09E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM81875(Fluoxetine-R-(-))

Ki: 3.10E+3nMMore data for this Ligand-Target Pair

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MCE
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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M2(RAT)
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.10E+3nMMore data for this Ligand-Target Pair

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CHEMBL DrugBank MCE
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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.16E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.17E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Histamine H1 receptor(RAT)
TBA

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.20E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: 3.39E+3nMMore data for this Ligand-Target Pair

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CHEMBL DrugBank MCE
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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.60E+3nMMore data for this Ligand-Target Pair

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Beta-arrestin-2(Beef)
Eli Lilly

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: 3.63E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.76E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.80E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/TrEMBL
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5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Eli Lilly

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: 3.89E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Recherches Servier

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 3.98E+3nMAssay Description:In vitro binding affinity against alpha-1 adrenergic receptor of rat in presence of [3H]-prazosin radioligandMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 4.27E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 4.58E+3nMAssay Description:Ability to inhibit high affinity reuptake of [3H]DA from dopamine transporter into nerve endings synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 4.75E+3nMMore data for this Ligand-Target Pair

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CHEMBL DrugBank MCE
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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM81875(Fluoxetine-R-(-))

Ki: 4.97E+3nMMore data for this Ligand-Target Pair

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MCE
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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.00E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.00E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Institut De Recherches Servier

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.01E+3nMAssay Description:In vitro binding affinity against alpha-2 adrenergic receptor of rat in presence of [3H]-RX 821002 radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.03E+3nMMore data for this Ligand-Target Pair

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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Institut De Recherches Servier

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.26E+3nMAssay Description:Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair

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Histamine H1 receptor(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.40E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: 5.89E+3nMMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 5.96E+3nMMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 6.00E+3nMAssay Description:Inhibition constant against dopamine transporterMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 6.17E+3nMMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 6.67E+3nM ΔG°: -29.2kJ/mole EC50: 1.95E+4nMpH: 7.4 T: 2°CAssay Description:Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...More data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 6.67E+3nMAssay Description:Displacement of [125I]RTI55 from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30E+3nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30E+3nMAssay Description:Displacement of N-[3H]alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30E+3nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 7.30E+3nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 8.31E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Beta-2 adrenergic receptor(Rattus norvegicus)
TBA

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Mcneil Pharmaceutical

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(RAT)
TBA

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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MCE
MMDB PC cid PC sid PDB Patents Similars

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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MCE
MMDB PC cid PC sid PDB Patents Similars

PDB Reactome pathway
UniProtKB/TrEMBL
GoogleScholar

5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Eli Lilly

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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MCE
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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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5-hydroxytryptamine receptor 3A(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 3A(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM81875(Fluoxetine-R-(-))

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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MCE
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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 3A(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
antibodypedia GoogleScholar

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
antibodypedia GoogleScholar

Alpha-2A adrenergic receptor(Homo sapiens (Human))
Institut De Recherches Servier

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Nih

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Soochow University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 1.61E+4nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat brain membranes in presence of (+)-pentazocine by scintillation counting methodMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Cytochrome P450 2C8(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.94E+5nMAssay Description:Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant systemMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 2.5nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 3.10nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 3.58nMpH: 7.4Assay Description:5-HT transporter binding assay for evaluating binding of the compound to the serotonin transporter was carried out using human recombinant serotonin ...More data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 3.60nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4nMAssay Description:Displacement of [3H]imipramine from SERT receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 5.20nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 6.30nMAssay Description:Binding affinity against Serotonin transporter in rat cerebral cortex using [3H]paroxetine binding assay.More data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 7nMAssay Description:Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 7.20nMAssay Description:Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of [3H]hydroxytryptamine creatinine sulfate uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of human SERT expressed in JAR cells assessed as serotonin uptakeMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of 5HT uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR celsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 9.40nMAssay Description:Inhibition of SERT-mediated serotonin uptake in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 10nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 10nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 12.6nMAssay Description:Displacement of [3H]paroxetine from SERT in rat cerebral cortexMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 13nMAssay Description:Inhibitory activity to dihydrofolate reductase in Escherichia coliMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 15nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A/1B/1D/1F(RAT)
TBA

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 15nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 16nMAssay Description:Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 16nMAssay Description:Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 32.4nMAssay Description:Inhibition concentration against [3H]-5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 39.4nMAssay Description:Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 39.4nMAssay Description:Inhibition of [3H]5-HT uptake at human 5-HT transporter expressed in Jar cellsMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Korea University Of Science And Technology (Ust)

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 40nMAssay Description:Inhibition of CYP2C19 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 47nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 47nMAssay Description:Inhibition of serotonin uptake at human SERT in human HEK293 cellsMore data for this Ligand-Target Pair

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Cytochrome P450 2C19(Homo sapiens (Human))
Korea University Of Science And Technology (Ust)

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 65nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >100nMAssay Description:Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]-spiperone in rat striatal membranesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 130nMAssay Description:Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenateMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Acetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 130nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 150nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 150nMAssay Description:Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 150nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 160nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 180nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 180nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 457nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 563nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 563nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK cellsMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 710nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of North Carolina

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 851nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar

Transporter(Rattus norvegicus)
Hong Kong University Of Science And Technology

Curated by ChEMBL

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

IC50: >1.00E+3nMAssay Description:Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar ratsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

IC50: >1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by PDSP K_i Database

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

IC50: >1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranesMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM50136166((3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)pheno...)

IC50: >1.00E+3nMAssay Description:Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar ratsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.02E+3nMAssay Description:Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.51E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.51E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.51E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 2.00E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 2.00E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET in human HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 2.54E+3nMpH: 7.4Assay Description:NE transporter binding assay for evaluating binding of the compound to the norepinephrine transporter was carried out using human recombinant norepin...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 2.82E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 3.10E+3nMAssay Description:Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4.40E+3nMAssay Description:Inhibition of DA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4.40E+3nMAssay Description:Inhibition of [3H]DA reuptake at DA transporter in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4.41E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4.41E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4.41E+3nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 5.20E+3nMAssay Description:Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 5.20E+3nMAssay Description:Inhibition of [3H]NA reuptake at NA transporter in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 6.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 6.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT in human HEK293 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 6.00E+3nMAssay Description:Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Veterans Administration Medical Center

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 8.30E+3nMAssay Description:Displacement of [3H]5-HT from of SERT in rat midbrain homogenates after 5 mins by scintillation countingMore data for this Ligand-Target Pair

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Acetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.00E+4nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.00E+4nMpH: 7.4Assay Description:DA transporter binding assay for evaluating binding of the compound to the dopamine transporter was carried out using human recombinant dopamine tran...More data for this Ligand-Target Pair

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Acetylcholinesterase(Mus musculus (mouse))
China Pharmaceutical University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.00E+4nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.00E+4nMAssay Description:Displacement of [3H]astemizole from human ERGMore data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Korea Institute of Science and Technology

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily C member 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.31E+4nMAssay Description:Inhibition of rat voltage-gated K channel 3.1 expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair

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Potassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.40E+4nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.84E+4nMAssay Description:Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.84E+4nMAssay Description:Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.84E+4nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair

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Potassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.90E+4nMAssay Description:Inhibition of of human TREK1 expressed in tsA201 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.95E+4nMAssay Description:Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ubiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair

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Cytochrome P450 2J2(Homo sapiens (Human))
Tongji University

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair

Reactome pathway
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ATP-dependent translocase ABCB1(Homo sapiens (Human))
University of Heidelberg

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.16E+5nMAssay Description:TP_TRANSPORTER: cell accumulation of calcein in L-MDR1 cellsMore data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 1.44E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair

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Cytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

IC50: 4.75E+5nMAssay Description:Inhibition of CYP1B1 (unknown origin) expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 7-Ethoxyresorufin as subst...More data for this Ligand-Target Pair

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Potassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

BDBM81875(Fluoxetine-R-(-))

EC50: 1.90E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
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Albumin(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Kd: 3.61E+4nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Kd: 0.810nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERTMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Kd: 3.60E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Kd: 240nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

EC50: 2.70nMAssay Description:Inhibition of human SERT-mediated serotonin reuptake in HEK293 cellsMore data for this Ligand-Target Pair

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