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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 22 hits in this display   

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  510nMAssay Description:Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  3.06E+3nMAssay Description:Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemiluminescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant human PTP1B using pNPP as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  1.41E+4nMAssay Description:Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human CYP1B1 expressed in HEK293 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human CYP1B1 expressed in MDA-MB-468 cells assessed as cell toxicityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in yeast microsomal membranes by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP2D6 expressed in HEK293 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in yeast microsomal membranes by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP3A4 expressed in HEK293 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in yeast microsomal membranes by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP1A1 transfected in HEK293 cells assessed as cell toxicityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP1A expressed in HEK293 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in yeast microsomal membranes by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP1A2 expressed in HEK293 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataIC50:  3.75E+4nMAssay Description:Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataEC50:  5.20E+3nMAssay Description:Inhibition of human CYP1B1 expressed in MDA-MB-468 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 20...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM69609((2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)...)
Affinity DataEC50:  5.84E+4nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCytochrome P450 1A1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50453918(CHEMBL4078418)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of human CYP1A1 transfected in HEK293 cells assessed as protection against CYP1A1 mediated B[a]P toxicity by measuring B[a]P EC50 at 20 uM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed