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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetCathepsin K(Homo sapiens (Human))
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human cathepsin K by gelatin zymographic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense MVAT4 rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM35493((2R,3R)-3-[[(1S)-1-(4-guanidinobutylcarbamoyl)-3-m...)
Affinity DataIC50:  4.46nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCathepsin B(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM35493((2R,3R)-3-[[(1S)-1-(4-guanidinobutylcarbamoyl)-3-m...)
Affinity DataIC50:  12.3nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProcathepsin L(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM35493((2R,3R)-3-[[(1S)-1-(4-guanidinobutylcarbamoyl)-3-m...)
Affinity DataIC50:  19.9nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain-2(Plasmodium falciparum)
Universidad Central De Venezuela

LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  58nMpH: 5.5 T: 2°CAssay Description:The substrate peptide terminating in AMC is processed by falcipain-2 with or without inhibitors, and the accumulation of AMC was monitored in a Labsy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  68nMAssay Description:Inhibition of Plasmodium falciparum N-terminal His6-tagged falcipain-2 (35 residues) expressed in Escherichia coli M15 pREP4 using Z-Lue-Arg-AMC as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine proteinase falcipain 3(Plasmodium falciparum)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  136nMAssay Description:Inhibition of Plasmodium falciparum N-terminal His-tagged falcipain-3 (33 residues) expressed in Escherichia coli M15 pREP4 using Z-Leu-Arg-AMC as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  3.00E+3nMAssay Description:Irreversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  5.72E+4nMAssay Description:Inhibition of Plasmodium falciparum FP2 using Z-Leu-Arg-AMC as substrate preincubated for 30 min followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed