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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plat...
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting method
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Binding affinity to human ERG channel
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Displacement of [3H]-diltiazem from human Cav1.2 channel
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of human Nav1.2 channel expressed in Xenopus oocytes by two-intracellular microelectrode voltage clamp method
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes assessed as dextraomethorphan O-demethylation
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac alpha'-hydroxylation
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP1A2 in human liver microsomes
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2C19 in human liver microsomes
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Target
Cytochrome P450 2C8
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2C8 in human liver microsomes
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Target
Cytochrome P450 2B6
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2B6 in human liver microsomes
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Target
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: >3.00E+4nM
Assay Description:
Activation of human PX receptor
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Target
Beta-3 adrenergic receptor
(Rattus norvegicus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: 86nM
Assay Description:
Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Macaca mulatta)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: 0.570nM
Assay Description:
Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Rattus norvegicus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: 122nM
Assay Description:
Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence ...
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: 1.60nM
Assay Description:
Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presenc...
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Target
Beta-3 adrenergic receptor
(Macaca mulatta)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: 7.10nM
Assay Description:
Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in...
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Target Info
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Target
Beta-3 adrenergic receptor
(Canis familiaris)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Affinity Data
EC50: 11nM
Assay Description:
Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50146154
(KRP-114V | MK-4618 | Vibegron)
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Copy InChI
Affinity Data
EC50: 1.10nM
Assay Description:
Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
More data for this Ligand-Target Pair
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