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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50540171(CHEMBL4643727)
Affinity DataIC50:  18nMAssay Description:Inhibition of BACE1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBeta-secretase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50540171(CHEMBL4643727)
Affinity DataIC50:  22nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50540171(CHEMBL4643727)
Affinity DataIC50:  28nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50540171(CHEMBL4643727)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human BACE1 using (MCA)-S-E-V-N-L-D-A-E-F-R-K(dinitrophenol)-R-R-R-R-NH2 as substrate incubated for 8 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50540171(CHEMBL4643727)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50540171(CHEMBL4643727)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Cathepsin D by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed