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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 14 hits in this display   

TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  35nMAssay Description:Inhibition of HDAC6 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  102nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  102nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed