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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  850nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  855nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform D of Beta-secretase 1 (BACE-I-432)(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  855nMpH: 4.5 T: 2°CAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50:  1.63E+3nMpH: 4.5 T: 2°CAssay Description:This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM50078324(CHEMBL3414708 | US9260455, 8)
Affinity DataIC50: >9.14E+4nMAssay Description:Inhibition of CatD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed