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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078320
(CHEMBL3414700 | US9260455, 4)
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Affinity Data
IC50: 59nM
Assay Description:
Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Beta-secretase 1
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078320
(CHEMBL3414700 | US9260455, 4)
Copy SMILES
Copy InChI
Affinity Data
IC50: 670nM
Assay Description:
Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Isoform D of Beta-secretase 1 (BACE-I-432)
(Homo sapiens (Human))
Pfizer
US Patent
Ligand
BDBM50078320
(CHEMBL3414700 | US9260455, 4)
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Affinity Data
IC50: 672nM
pH: 4.5 T: 2°C
Assay Description:
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Beta-secretase 2
(Homo sapiens (Human))
Pfizer
US Patent
Ligand
BDBM50078320
(CHEMBL3414700 | US9260455, 4)
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Affinity Data
IC50: 2.14E+3nM
pH: 4.5 T: 2°C
Assay Description:
This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Cathepsin D
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078320
(CHEMBL3414700 | US9260455, 4)
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Affinity Data
IC50: 8.31E+4nM
Assay Description:
Inhibition of CatD (unknown origin) by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI