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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078322
(CHEMBL3414710)
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Affinity Data
IC50: 24nM
Assay Description:
Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Beta-secretase 1
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078322
(CHEMBL3414710)
Copy SMILES
Copy InChI
Affinity Data
IC50: 280nM
Assay Description:
Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM238984
(US9403846, 2)
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Affinity Data
IC50: 281nM
pH: 4.5
Assay Description:
A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078322
(CHEMBL3414710)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of CYP2D6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Beta-secretase 2 [21-466]
(Homo sapiens (Human))
Pfizer
US Patent
Ligand
BDBM238984
(US9403846, 2)
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Affinity Data
IC50: 2.26E+3nM
pH: 4.5 T: 2°C
Assay Description:
A synthetic substrate that can be cleaved by BACE2 having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Green at the Cy...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cathepsin D
(Homo sapiens (Human))
Eurofarma Laboratorios
Curated by
ChEMBL
Ligand
BDBM50078322
(CHEMBL3414710)
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Affinity Data
IC50: 4.50E+4nM
Assay Description:
Inhibition of CatD (unknown origin) by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI