SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 35 hits in this display

Carbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 0.5nM ΔG°: -52.2kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 12(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 0.900nM ΔG°: -50.8kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 12(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 2.80nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 9(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 4.90nM ΔG°: -46.6kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 9(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50547696(CHEMBL1209038)

Ki: 6.40nMAssay Description:Inhibition of recombinant human CA9 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Carbonic anhydrase 9(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 6.40nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 14(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 7.5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 2(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 10nM ΔG°: -44.9kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 10nMAssay Description:Inhibition of human carbonic anhydrase-2 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed MMDB

Carbonic anhydrase 2(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 10nMAssay Description:Inhibitory effect on human Carbonic anhydrase IIMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed MMDB

Carbonic anhydrase 2(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 11nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed MMDB

Carbonic anhydrase 2(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50547696(CHEMBL1209038)

Ki: 11nMAssay Description:Inhibition of recombinant human CA2 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Carbonic anhydrase 14(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL

PNG

BDBM82103(Investigational agent, 4)

Ki: 13nM ΔG°: -44.3kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 34nM ΔG°: -41.9kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 13(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 34nM ΔG°: -41.9kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 35nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 6(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 46nM ΔG°: -41.2kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 4(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 56nM ΔG°: -40.7kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 4(Bos taurus (bovine))
University Of Namur

Curated by ChEMBL

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 65nMAssay Description:Inhibitory effect on bovine Carbonic anhydrase IVMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 78nM ΔG°: -39.9kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 13(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 118nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 4(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50547696(CHEMBL1209038)

Ki: 349nMAssay Description:Inhibition of recombinant human CA4 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Carbonic anhydrase 4(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 349nMAssay Description:Inhibition of human recombinant carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 440nMAssay Description:Inhibition of human recombinant carbonic anhydrase 5b after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 448nMAssay Description:Inhibition of human recombinant carbonic anhydrase 5a after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 15(Mus musculus)
University Of Florida

Curated by ChEMBL

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 652nMAssay Description:Inhibition of mouse recombinant carbonic anhydrase 15 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 6(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 765nMAssay Description:Inhibition of human recombinant carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM82103(Investigational agent, 4)

Ki: 850nM ΔG°: -34.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 850nMAssay Description:Inhibition of human carbonic anhydrase-1 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 850nMAssay Description:Inhibitory effect on human carbonic anhydrase IMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 883nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

PNG

BDBM50547696(CHEMBL1209038)

Ki: 883nMAssay Description:Inhibition of recombinant human CA1 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Carbonic anhydrase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 3.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Carbonic anhydrase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL

PNG

BDBM82103(Investigational agent, 4)

Ki: 3.10E+5nM ΔG°: -19.7kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed

Carbonic anhydrase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL

PNG

BDBM50108563(Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]t...)

Ki: 1.20E+6nMAssay Description:Inhibition of human carbonic anhydrase-3 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid Similars

Details Article PubMed

Filter my 35 hits

Targets 13▿
- Carbonic anhydrase 1 5
- Carbonic anhydrase 2 5
- Carbonic anhydrase 4 4
- Carbonic anhydrase 9 3
- Carbonic anhydrase 3 3
- Carbonic anhydrase 12 2
- Carbonic anhydrase 14 2
- Carbonic anhydrase 13 2
- Carbonic anhydrase 6 2
- Carbonic anhydrase 7 2
- Carbonic anhydrase 5A, mitochondrial 2
- Carbonic anhydrase 5B, mitochondrial 2
- Carbonic anhydrase 15 1
Publications 5▿
- Bioorg Med Chem Lett 20: 4376-81 (2010) 13
- Chem Biol Drug Des 74: 317-21 (2009) 12
- J Med Chem 63: 13064-13075 (2020) 4
- Bioorg Med Chem 21: 2314-8 (2013) 3
- J Med Chem 45: 312-20 (2002) 3
Institutions 3▿
- University Of Florida 20
- Istituto Di Biostrutture E Bioimmagini-Cnr 12
- University Of Namur 3
Affinity: 0.5 to 1.2E+6 nM▿
- Ki 35
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 1
Catalog Cmpds: 0