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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 22 hits in this display   

TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of human recombinant DAO expressed in Escherichia coli BL21(DE3) by oxygraphic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  1.09E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 20(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Candida albicans (Yeast))
Università

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  2.44E+4nMAssay Description:Inhibition of Candida albicans Nce103More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of human carbonic anhydrase2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  3.00E+4nMAssay Description:Binding affinity against human cytosolic Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase [110-330](Flaveria bidentis (Coastal plain yellowtops))
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  6.45E+4nM ΔG°:  -23.5kJ/molepH: 8.3 T: 2°CAssay Description:Inhibition constants of carboxylate inhibitors against F. bidentis CA I were determined by a stopped flow CO2 hydration assay at 20 °C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  7.47E+4nMAssay Description:Binding affinity against human cytosolic Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  2.53E+5nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  7.30E+5nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  7.01E+6nMAssay Description:Binding affinity against human cytosolic Carbonic anhydrase VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi: >1.50E+8nMAssay Description:Binding affinity against human cytosolic Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataIC50:  2.09E+3nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataIC50:  4.69E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataIC50:  6.57E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Homo sapiens (Human))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine racemase(Homo sapiens (Human))
Kitasato University

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKd:  9.00E+3nMAssay Description:Binding affinity to human recombinant DAAO at 442 nm spectral modification by spectrophotometric analysis in presence of FADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to human recombinant DAAO by stopped flow spectrophotometric analysis in presence of FADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to human recombinant DAAO at 492 nm spectral modification by spectrophotometric analysis in presence of FADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed