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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  68nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  68nMAssay Description:Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataKi:  616nMAssay Description:Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataIC50: >1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataIC50: >1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataEC50:  3.98E+3nMAssay Description:Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM181143(US9138393, Immepip dihydrobromide | US9144538, Imm...)
Affinity DataEC50:  49nMAssay Description:Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed