Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM50432607
(CHEMBL2347205 | US8754075, 33)
Copy SMILES
Copy InChI
Affinity Data
IC50: 27nM
T: 2°C
Assay Description:
The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM50432607
(CHEMBL2347205 | US8754075, 33)
Copy SMILES
Copy InChI
Affinity Data
IC50: 27nM
Assay Description:
Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as reduction of amyloid beta40 level after 18 to 20 hrs by AlphaLIS...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM50432607
(CHEMBL2347205 | US8754075, 33)
Copy SMILES
Copy InChI
Affinity Data
IC50: 435nM
Assay Description:
Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM50432607
(CHEMBL2347205 | US8754075, 33)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.17E+3nM
Assay Description:
Inhibition of recombinant human BACE1 (43 to 454 residues) expressed in Escherichia coli BL21(DE3) using Biotin-epsilon-amino-n-capronic acid-SEVNLDA...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 2
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM50432607
(CHEMBL2347205 | US8754075, 33)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.17E+3nM
T: 2°C
Assay Description:
The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
Copy BDB DOI