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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  1.73nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  108nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  1.57E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  3.92E+5nMAssay Description:Inhibition of CatE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  4.95E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CatD is 0.05M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50:  5.35E+5nMAssay Description:Inhibition of CatD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed