Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50349211(CHEMBL1807652)Copy SMILESCopy InChI

Affinity DataIC50:  31.9nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50349211(CHEMBL1807652)Copy SMILESCopy InChI

Affinity DataIC50:  44.5nMAssay Description:Inhibition of human recombinant cathepsin K using z-LR-AFC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50349211(CHEMBL1807652)Copy SMILESCopy InChI

Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of cathepsin S in human Raji cells assessed as decrease in cell surface expression of MHC class 2/CLIP by flow cytometric analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI