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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human))
Astex Therapeutics
US Patent
Ligand
BDBM156148
(US9018214, 199)
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Affinity Data
IC50: 63nM
pH: 7.5 T: 2°C
Assay Description:
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
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Target
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM156148
(US9018214, 199)
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Affinity Data
EC50: 2.40nM
Assay Description:
Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrs
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human))
Astex Therapeutics
US Patent
Ligand
BDBM156148
(US9018214, 199)
Copy SMILES
Copy InChI
Affinity Data
EC50: 69nM
Assay Description:
Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI