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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510806(CHEMBL4565391)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of BACE1 in human SK-N-BE(2) cells expressing human APP695 assessed as reduction in amyloidbeta (1 to 42 residues) level incubated for 18 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510806(CHEMBL4565391)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 120 mins using APP swedish mutant as substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510806(CHEMBL4565391)
Affinity DataIC50:  17nMAssay Description:Inhibition of BACE2 (unknown origin) incubated for 450 mins using APP swedish mutant as substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed