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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258310(US9493485, 9-151)
Affinity DataIC50:  5nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258310(US9493485, 9-151)
Affinity DataIC50:  9.70nMpH: 7.0Assay Description:BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258310(US9493485, 9-151)
Affinity DataIC50: >3.00E+4nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent