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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Amyloid-beta precursor protein
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Beta-secretase 1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of human recombinant BACE1 catalytic domain using FRET substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Beta-secretase 2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of human recombinant BACE2 catalytic domain using FRET substrate
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: 7.00E+3nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated 10 mins in presence of NADPH by solid phase extraction mass spe...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated 10 mins in presence of NADPH by solid phase extraction mass spe...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated 10 mins in presence of NADPH by solid phase extraction mass sp...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Cathepsin D
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50587070
(CHEMBL5090563)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of human cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI