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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
39
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
Ki: 630nM
Assay Description:
Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cells
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 630nM
Assay Description:
Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...
More data for this Ligand-Target Pair
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
Ki: 660nM
Assay Description:
Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 960nM
Assay Description:
Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cells
More data for this Ligand-Target Pair
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
Ki: 960nM
Assay Description:
Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
Ki: 1.13E+3nM
Assay Description:
Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cells
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
Ki: 2.85E+3nM
Assay Description:
Displacement of [125I]CYP from human adrenergic beta 2 receptor transfected in CHO cells in presence of 100 uM GTP
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
Ki: 1.13E+4nM
Assay Description:
Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...
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Target
Beta-2 adrenergic receptor
(Canis familiaris)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 9.10nM
Assay Description:
Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterus
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 9.10nM
Assay Description:
Inhibition of spontaneous contractions in isolated rat uterus
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 9.12nM
Assay Description:
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 190nM
Assay Description:
Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos...
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Compound was evaluated for its binding affinity towards Beta-2 adrenergic receptor in rat soleus membrane by displacing (-)-isoproterenol (50 microM)
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Beta-2 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.00E+3nM
Assay Description:
Beta-1 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol
More data for this Ligand-Target Pair
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 1.10nM
Assay Description:
Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method
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Target
Beta-3 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 2.19nM
Assay Description:
Agonistic activity towards beta-3 adrenoceptor. Mean concentration required to produce 50% relaxation of detrusor before the addition in the ferret d...
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 680nM
Assay Description:
Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cells
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human))
American Cyanamid
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 5.60E+3nM
Assay Description:
Compound was evaluated for its binding affinity towards Beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 1.70E+3nM
Assay Description:
Agonist activity at Homo sapiens (human) beta1 adrenoreceptor
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
EC50: 290nM
Assay Description:
Agonist activity at Homo sapiens (human) beta2 adrenoreceptor
More data for this Ligand-Target Pair
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
EC50: 450nM
Assay Description:
Agonism against Beta-3 adrenergic receptor
More data for this Ligand-Target Pair
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
EC50: 2.20nM
Assay Description:
Concentration required to effect a 50% relaxation of ferret detrusor basal tone
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
EC50: 0.0950nM
Assay Description:
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Copy SMILES
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Affinity Data
EC50: 21nM
Assay Description:
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 1.70E+3nM
Assay Description:
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002598
(CHEMBL152535)
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Affinity Data
EC50: 50nM
Assay Description:
Ability to cause cAMP accumulation in CHO cells expressing human beta-2 AR expressed as the negative logarithm of the molar drug concentration
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002598
(CHEMBL152535)
Copy SMILES
Copy InChI
Affinity Data
EC50: 25nM
Assay Description:
Ability to cause cAMP accumulation in CHO cells expressing human beta-3 AR expressed as the negative logarithm of the molar drug concentration
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002598
(CHEMBL152535)
Copy SMILES
Copy InChI
Affinity Data
EC50: <794nM
Assay Description:
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 450nM
Assay Description:
Compound was evaluated for agonistic activity in human Beta-3 adrenergic receptor assay; partial weak agonist
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002598
(CHEMBL152535)
Copy SMILES
Copy InChI
Affinity Data
EC50: 50nM
Assay Description:
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002598
(CHEMBL152535)
Copy SMILES
Copy InChI
Affinity Data
EC50: <794nM
Assay Description:
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002598
(CHEMBL152535)
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Affinity Data
EC50: 25nM
Assay Description:
Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 5.90nM
Assay Description:
Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 290nM
Assay Description:
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
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Beta-3 adrenergic receptor
(Rattus norvegicus)
Kissei Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 8.40nM
Assay Description:
Compound was evaluated in vitro for beta-adrenergic activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol...
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 21nM
Assay Description:
Agonist activity at Homo sapiens (human) beta3 adrenoreceptor
More data for this Ligand-Target Pair
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antibodypedia
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CHEMBL
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Target
Beta-3 adrenergic receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50002133
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
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Affinity Data
EC50: 680nM
Assay Description:
Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO-beta-3 adrenergic receptor cell membrane.
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CHEMBL
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