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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetProteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  260nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  270nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  270nMAssay Description:Inhibition of HDAC6 (unknown origin) by multilabel plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  394nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  530nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  530nMAssay Description:Inhibition of HDAC8 (unknown origin) by multilabel plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  821nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of C-terminal FLAG-His-tagged full length recombinant human HDAC1 expressed in Sf21 insect cells using RHKK(Ac)AMC as substrate by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of recombinant human HDAC3/NCOR2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50450706(CHEMBL4167623)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed