Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 20 hits in this display
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: 5nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with APP695 assessed as reduction in APP level incubated for 18 hrs by ELISAMore data for this Ligand-Target Pair
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: 37nMAssay Description:Inhibition of human BACE1 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: 41nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: 73nMpH: 4.5 T: 2°CAssay Description:The substrate is Biotin-GLTNIKTEEISEISY^EVEFR-C[Oregon Green]KK-OH. The BACE1 enzyme is affinity purified material from conditioned media of CHO-K1 c...More data for this Ligand-Target Pair
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: 238nMAssay Description:Inhibition of human BACE2 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: 2.36E+4nMT: 2°CAssay Description:All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). ...More data for this Ligand-Target Pair
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
BDBM223395(US9315520, 1 | US9315520, Comparator 1 | US9315520...)
IC50: >1.00E+5nMpH: 4.5 T: 2°CAssay Description:The substrate is Biotin-GLTNIKTEEISEISY^EVEFR-C[Oregon Green]KK-OH. The BACE1 enzyme is affinity purified material from conditioned media of CHO-K1 c...More data for this Ligand-Target Pair