Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Kallikrein-1
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: 25nM
Assay Description:
Inhibition of purified human tissue kallikrein 1 using H-D-Val-Leu-Arg-AFC as substrate
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor VII/Tissue factor
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Inhibition of recombinant human Tissue factor/factor 7a using S2288 as substrate after 30 to 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor VII
(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: >140nM
Assay Description:
FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.50E+3nM
Assay Description:
Inhibition of purified human factor 10a using S2765 as substrate after 30 to 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.70E+3nM
Assay Description:
Inhibition of purified human thrombin after 30 to 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Trypsin
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: >6.20E+3nM
Assay Description:
Inhibition of purified human trypsin after 30 to 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor XI
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM189415
(US9174974, Comparator 4)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.10E+3nM
Assay Description:
Inhibition of purified human factor 11a after 30 to 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI