Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetKallikrein-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi:  25nMAssay Description:Inhibition of purified human tissue kallikrein 1 using H-D-Val-Leu-Arg-AFC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi:  140nMAssay Description:Inhibition of recombinant human Tissue factor/factor 7a using S2288 as substrate after 30 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi: >140nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of purified human factor 10a using S2765 as substrate after 30 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of purified human thrombin after 30 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi: >6.20E+3nMAssay Description:Inhibition of purified human trypsin after 30 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM189415(US9174974, Comparator 4)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition of purified human factor 11a after 30 to 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed