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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/Serine/threonine-protein kinase B-raf
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM200464
(US10011599, Example 93 | US9227969, 93 | US9629836...)
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Affinity Data
IC50: 25nM
pH: 7.5
Assay Description:
A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM200464
(US10011599, Example 93 | US9227969, 93 | US9629836...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 25nM
Assay Description:
[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1 [K97R]
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM200464
(US10011599, Example 93 | US9227969, 93 | US9629836...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 25nM
Assay Description:
The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI