SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 58 hits in this display

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Ki: <0.200nM ΔG°: <-55.4kJ/mole IC50: 1nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Ki: <0.200nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Ki: 1.5nM ΔG°: -50.4kJ/mole IC50: 13nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Ki: 1.5nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Ki: 500nM ΔG°: -36.0kJ/mole IC50: 398nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Ki: 500nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 1nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 7nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 7nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 10.1nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 13nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 40nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 40nMAssay Description:Inhibition of recombinant HDAC1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 40nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 40nMAssay Description:Inhibition of wild-type FLAG-tagged HDAC1 (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 49nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 49nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 56.3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 70nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using substrate after 90 m...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 70nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using substrate after...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 100nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 100nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 100nMAssay Description:Inhibition of recombinant HDAC2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 204nMAssay Description:Inhibition of FLAG-tagged HDAC1 S113A mutant (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analy...More data for this Ligand-Target Pair

PDB KEGG
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3D Structure (crystal)

Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 398nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Polyamine deacetylase HDAC10(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 3.40E+3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 8(Homo sapiens (Human))
Wayne State University

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 8(Homo sapiens (Human))
Wayne State University

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 4(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histone deacetylase 6(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 7(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 5(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Histone deacetylase 9(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 1.00E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 8(Homo sapiens (Human))
Wayne State University

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 7(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 6(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 4(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histone deacetylase 5(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair

Reactome pathway KEGG
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Histone deacetylase 4(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histone deacetylase 5(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Histone deacetylase 6(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 7(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 6(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 5(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair

Reactome pathway KEGG
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Histone deacetylase 4(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 8(Homo sapiens (Human))
Wayne State University

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 7(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 8(Homo sapiens (Human))
Wayne State University

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of recombinant HDAC3More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 6(Homo sapiens (Human))
Genentech

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of recombinant HDAC6More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 8(Homo sapiens (Human))
Wayne State University

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

IC50: >2.00E+4nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Kd: 55.2nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

PNG

BDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)

Kd: 38.1nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Displayed 1 to 50 (of 58 total ) | Next | Last >>

Filter my 58 hits

Targets 11▿
- Histone deacetylase 1 12
- Histone deacetylase 2 11
- Histone deacetylase 3 9
- Histone deacetylase 8 6
- Histone deacetylase 6 5
- Histone deacetylase 7 4
- Histone deacetylase 4 4
- Histone deacetylase 5 4
- Histone deacetylase 1
- Polyamine deacetylase HDAC10 1
- Histone deacetylase 9 1
- ...
Publications 10▿
- J Biol Chem 288: 26926-43 (2013) 12
- ACS Chem Biol 12: 254-264 (2017) 8
- J Med Chem 51: 1505-29 (2008) 8
- Bioorg Med Chem Lett 18: 973-8 (2008) 8
- Bioorg Med Chem 24: 4008-4015 (2016) 6
- Eur J Med Chem 45: 2095-116 (2010) 5
- J Med Chem 50: 5543-6 (2007) 4
- ACS Chem Biol 11: 363-74 (2016) 3
- J Med Chem 57: 642-50 (2014) 2
- ACS Med Chem Lett 9: 268-273 (2018) 2
Institutions 9▿
- Genentech 12
- Wayne State University 10
- Merck Research Laboratories 8
- Menarini Ricerche 8
- Broad Institute Of Mit And Harvard 6
- Universit£ 5
- Methylgene 4
- Broad Institute of Harvard and Mit 3
- Duke University Medical Center 2
Affinity: 0.20 to 2.0E+4 nM▿
- Ki 6
- IC50 53
- Kd 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1