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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Mansoura University
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
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Affinity Data
IC50: 0.700nM
Assay Description:
Inhibition of MEK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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MCE
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3D Structure (crystal)
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Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Mansoura University
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.920nM
Assay Description:
Inhibition of MEK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Mansoura University
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.920nM
Assay Description:
Non competitive inhibition of MEK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
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Target
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
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Affinity Data
IC50: <1nM
Assay Description:
Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levels
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
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MCE
PC cid
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
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Affinity Data
IC50: 1.80nM
Assay Description:
Non competitive inhibition of MEK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.80nM
Assay Description:
Inhibition of MEK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
Inhibition of MEK 1/2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Mansoura University
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.16nM
Assay Description:
The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1/2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.16nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
Inhibition of MEK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-University Of Bonn
Curated by
ChEMBL
Ligand
BDBM50531540
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
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Affinity Data
EC50: 247nM
Assay Description:
Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI