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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM335440((2,2-Dimethyl-propyl)-(4-piperazin-1-yl-pyrimidin-...)
Affinity DataKi:  39nMAssay Description:Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM335440((2,2-Dimethyl-propyl)-(4-piperazin-1-yl-pyrimidin-...)
Affinity DataKi:  186nMAssay Description:Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM335440((2,2-Dimethyl-propyl)-(4-piperazin-1-yl-pyrimidin-...)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of 5 nM [3H-pyrilamine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM335440((2,2-Dimethyl-propyl)-(4-piperazin-1-yl-pyrimidin-...)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of 3 nM [3H]Nalpha-methylhistamine from human H3R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition bind...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM335440((2,2-Dimethyl-propyl)-(4-piperazin-1-yl-pyrimidin-...)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of 20 nM [3H]UR-DE257 from human H2R expressed in Sf9 cell membranes co-expressing GsalphaS by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed