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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetCathepsin B(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi: >330nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  840nM ΔG°:  -36.1kJ/molepH: 6.5 T: 2°CAssay Description:Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Bos taurus (bovine))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  900nM ΔG°:  -35.9kJ/molepH: 6.0 T: 2°CAssay Description:Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.0kJ/molepH: 6.5 T: 2°CAssay Description:Papain enzyme activities were determined by spectrophotometric detection of the product p-nitroaniline at 25 C in a a multicell holder (parallel meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  6.30E+3nM ΔG°:  -30.9kJ/molepH: 5.0 T: 2°CAssay Description:Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed