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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50080250
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50080250
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
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Affinity Data
IC50: 1.70nM
Assay Description:
Displacement of [3H]3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzyl-indol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50080250
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
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Affinity Data
IC50: 3nM
Assay Description:
Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50080250
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
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Affinity Data
IC50: 12nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50080250
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
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Affinity Data
IC50: >30nM
Assay Description:
Inhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arachidonate 5-lipoxygenase-activating protein/Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50080250
(3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(pyridi...)
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Affinity Data
IC50: 50nM
Assay Description:
Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
Copy BDB DOI