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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Replicase polyprotein 1ab
(2019-nCoV)
Institut Pasteur Korea
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: 6.57E+3nM
Assay Description:
Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of human ERG
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2D6 (unknown origin)
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP3A4 (unknown origin)
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Target
Cytochrome P450 2E1
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2E1 (unknown origin)
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2C19 (unknown origin)
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2C9 (unknown origin)
More data for this Ligand-Target Pair
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP1A2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
EC50: 131nM
Assay Description:
Potentiation of CFTR G551D mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence ...
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3D Structure (crystal)
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Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
EC50: 68nM
Assay Description:
Potentiation of CFTR F508 deletion mutant (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskoli...
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Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Copy InChI
Affinity Data
EC50: 70nM
Assay Description:
Potentiation of wild-type CFTR (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence of ...
More data for this Ligand-Target Pair
Target Info
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MCE
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PubMed
PDB
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Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 49nM
Assay Description:
Potentiation of CFTR F508del mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presenc...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
DrugBank
MCE
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 12nM
Assay Description:
Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...
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Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
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Affinity Data
EC50: 3nM
Assay Description:
Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay
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Target Info
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MCE
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Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 22nM
Assay Description:
Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording technique
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
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DrugBank
MCE
PC cid
PC sid
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 236nM
Assay Description:
Potentiation of human CFTR F508del mutant in human bronchial epithelial cells by Ussing chambers recording technique
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
UniProtKB/SwissProt
antibodypedia
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Ligand Info
Purchase
DrugBank
MCE
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 34nM
Assay Description:
Potentiation of wild type CFTR (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskolin and amilo...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
DrugBank
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 236nM
Assay Description:
Corrector activity at human bronchial epithelium CFTR F508del and G551D mutant assessed as increase in channel gating
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
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Ligand Info
Purchase
DrugBank
MCE
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50032693
(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Copy SMILES
Copy InChI
Affinity Data
EC50: 3nM
Assay Description:
Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assay
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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DrugBank
MCE
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PDB
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Copy BDB DOI