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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Calmodulin-domain protein kinase 1
(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM340940
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
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Affinity Data
IC50: 171nM
Assay Description:
Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Calmodulin-domain protein kinase 1
(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM340940
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
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Copy InChI
Affinity Data
IC50: 171nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
cGMP-dependent protein kinase
()
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM340940
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
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Copy InChI
Affinity Data
IC50: 171nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For
US Patent
Ligand
BDBM340940
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
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Affinity Data
IC50: 1.16E+3nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM340940
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.16E+3nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Calcium-dependent protein kinase 1
(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM340940
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.16E+3nM
Assay Description:
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI