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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
hits in this display
Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
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Affinity Data
Ki: 0.180nM
Assay Description:
Inhibition of human cathepsin K
More data for this Ligand-Target Pair
Target Info
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Target
Cruzipain
(Trypanosoma cruzi)
Universidade De S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
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Affinity Data
Ki: 126nM
Assay Description:
Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition ...
More data for this Ligand-Target Pair
Target Info
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Target
Procathepsin L
(Homo sapiens (Human))
Universidade De S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
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Affinity Data
Ki: 1.26E+3nM
Assay Description:
Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate additi...
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of humanized rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of humanized rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of humanized rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of human cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of humanized rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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Target
Cathepsin K
(Homo sapiens (Human))
Cnrs Upr 4301
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70nM
Assay Description:
Inhibition of Cathepsin K (unknown origin) assessed as inhibition of AFC release using sequence LR labelled with AFC as substrate by fluorescence bas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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Target
Pro-cathepsin H
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: >10nM
Assay Description:
Inhibition of cathepsin H
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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CHEMBL
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PubMed
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Target
Cathepsin Z
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: >10nM
Assay Description:
Inhibition of cathepsin Z
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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Target
Dipeptidyl peptidase 1
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: >10nM
Assay Description:
Inhibition of cathepsin C
More data for this Ligand-Target Pair
Target Info
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Target
Cathepsin S
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
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Affinity Data
IC50: 45nM
Assay Description:
Inhibition of cathepsin S in human ramos cells
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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CHEMBL
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Target
Cathepsin S
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 60nM
Assay Description:
Inhibition of cathepsin S
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Cathepsin S
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 183nM
Assay Description:
Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PubMed
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Target
Cathepsin S
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: <500nM
Assay Description:
Inhibition of Cathepsin S (unknown origin) assessed as inhibition of AFC release using sequence VVR labelled with AFC as substrate by fluorescence ba...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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antibodypedia
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Target
Cathepsin L2
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 762nM
Assay Description:
Inhibition of cathepsin V
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
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CHEMBL
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PubMed
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Target
Cathepsin F
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 795nM
Assay Description:
Inhibition of cathepsin F
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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CHEMBL
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Target
Cathepsin B
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.03E+3nM
Assay Description:
Inhibition of cathepsin B
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PubMed
Copy BDB DOI
Target
Cathepsin B
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.05E+3nM
Assay Description:
Inhibition of cathepsin B in human HepG2 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PubMed
Copy BDB DOI
Target
Cathepsin B
(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: <2.00E+3nM
Assay Description:
Inhibition of Cathepsin B (unknown origin) assessed as inhibition of AFC release using sequence RR labelled with AFC as substrate by fluorescence bas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PubMed
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Target
Procathepsin L
(Homo sapiens (Human))
Universidade De S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of cathepsin L
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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PubMed
Copy BDB DOI
Target
Procathepsin L
(Homo sapiens (Human))
Universidade De S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50255753
(CHEMBL481611 | MK-0822 | Odanacatib)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.84E+3nM
Assay Description:
Inhibition of cathepsin L in human HepG2 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI