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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetCaspase-3(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50:  30nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50:  30nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50:  700nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50:  700nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-9(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-9(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-5(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-5(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent