Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataIC50:  193nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataIC50:  194nMAssay Description:Inhibition of recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS interaction with Nrf2 assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataIC50:  200nMAssay Description:Displacement of AF647-9-mer ETGE peptide from recombinant human biotinylated KEAP1 Kelch domain (322 to 609 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataEC50:  395nMAssay Description:Displacement of FITC-LDEETGEFL-NH2 from Keap1 Kelch domain (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50006933(CHEMBL3134422)
Affinity DataKd:  21nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed