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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
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Target
Cathepsin K
(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 120nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
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Target Info
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KEGG
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Target
Cathepsin S
(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 130nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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Target
Procathepsin L
(Bos taurus (bovine))
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
More data for this Ligand-Target Pair
Target Info
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Target
Cruzipain
(Trypanosoma cruzi)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 1.26E+3nM
Assay Description:
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...
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Target
Papain
(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 2.00E+3nM ΔG°: -32.5kJ/mole
pH: 6.5 T: 2°C
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...
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Target Info
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Target
Procathepsin L
(Homo sapiens (Human))
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 2.51E+3nM
Assay Description:
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...
More data for this Ligand-Target Pair
Target Info
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM20087
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
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Affinity Data
Ki: 9.40E+4nM
pH: 6.0
Assay Description:
Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysis
More data for this Ligand-Target Pair
Target Info
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